Gastric metastases from melanoma are often pigmented; however, they can be non-pigmented, mimicking other epithelial neoplasms and MALT lymphoma. These lesions may appear as multiple small-size nodules of the mucosa or submucosa, polypoid lesions or extrinsic masses.The prognosis of metastatic melanoma is very poor.Case summary:A 44-year-old man from Brazil, with no relevant medical history, presented to our emergency department with a one-month history of vespertine fever, weight loss and asthenia. Computerized tomography scan showed diffuse metastases in lung, liver, spleen and peritoneum. In order to rule out a GIT primary tumor, upper and lower endoscopy were performed. Upper endoscopy identified three sessile polypoid lesions with central erosion in the great curvature of the gastric body, as well as in the duodenum. Colonoscopy was normal.The histological examination of the biopsies was compatible with epithelioid neoplastic infiltration of the mucosa with immunohistochemistry positivity for SOX-10, consistent with metastasis of melanoma. A dermatologic inspection with epiluminescence was then performed and revealed a heterochromatic papule of the dorsum measuring about 1 cm, with a pearly edge. Incisional biopsy of that papule confirmed melanoma, reaching the reticular dermis in a thickness of at least 1.6mm. The diagnosis of disseminated melanoma was made. The patient started palliative chemotherapy, however the disease progressed and he died 7 months later.Relevance:This case highlights the different endoscopic appearance of melanoma mestastasis and the importance of performing biopsies of suspicious lesions even in metastatic disease.