Endoscopic submucosal dissection (ESD) is an endoscopic technique widely employed in Asia for resection of esophageal and esophagogastric junction (EGJ) neoplasms. In the West, ESD of these locations is limited to a very few centers. This study aims to report the feasibility, safety and effectiveness of ESD for the treatment of early neoplasms of the esophagus and EGJ in a Western center.